How it works

Apo B helps transport lipids throughout the bloodstream, which is vital for cardiovascular health. Along with other lipid tests, Apo B is a powerful risk marker for cardiovascular disease.

Measures the ratio of total cholesterol levels to high-density lipoprotein cholesterol (HDL).

HDL is part of a comprehensive lipid panel, an essential risk assessment for heart disease. There are two types of cholesterol: high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Think of the H as healthy, helpful, heart-supporting cholesterol that helps reduce plaque buildup.

Large HDL particles in the blood are protective; having a higher amount is beneficial because they help reduce the risk of cardiovascular disease.

hs-CRP is revelatory in one's overall health as it relates to the risk of inflammation-related diseases. Chronic inflammation is linked to every major disease: heart disease (even before symptoms occur), type 2 diabetes, cancer, high blood pressure, Alzheimer’s, depression, all autoimmune diseases, and severe allergic reactions like asthma.

This test is a risk marker for cardiovascular diseases. LDL is responsible for carrying cholesterol to cells. However, despite its good intentions, LDL is known as the “bad” cholesterol because, when levels are too high, it can cause the formation of plaque buildup in the arteries.

Measures the amount of medium LDL particles in the blood. Elevated medium LDL levels are associated with an increased risk of atherosclerosis and cardiovascular disease.

Measures the number of LDL particles, which are the carriers of cholesterol. Too many LDL particles can lead to plaque buildup in arteries, increasing the risk of heart disease and stroke.

Assesses the risk of cardiovascular disease
based on cholesterol health, either Pattern A or Pattern B.

Refers to the most common or average size of LDL particles in your blood. This is important because smaller LDL particles are more likely to contribute to plaque buildup in arteries, increasing the risk of cardiovascular disease.

Small LDL particles in the blood are harmful, as elevated levels are
linked to a higher risk of atherosclerosis and cardiovascular disease.

About 50% of people who suffer heart attacks have a normal cholesterol level. Considering this, many cardiologists believe Lp(a) to be a major driver of cardiac events. This invaluable test is used by specialists but is not yet widely adopted in primary care. Lp(a) is a genetic marker that determines risk, particularly for those with symptoms or a family history of cardiovascular disease. Lipoproteins are made of lipids (fats) and proteins (energy) and are referred to as "sticky proteins."

Measures cholesterol that is not HDL. This is a risk marker for
dyslipidemia, cardiovascular disease, and metabolic syndrome.

Total cholesterol numbers are part of a risk assessment for heart disease. Too much cholesterol in the blood can damage arteries and blood vessels and elevate the risk for stroke, heart attack, and heart disease. Cholesterol is a fatty substance produced by the liver to help with thousands of bodily functions, such as building cells, promoting hormone and brain function, and synthesizing vitamin D.

The ratio of triglycerides to HDL measures risk for heart disease. Triglycerides are the most common type of fat in the body that stores excess energy from one's diet. An accumulation of triglycerides means there is too much fat in the blood and may indicate higher risk of a cardiac event.

This test checks for antibodies created against thyroglobulin, a protein produced and used by the thyroid gland to make T3 and T4 hormones, which control metabolism and tissue/cell growth. If present, it may indicate thyroid-related autoimmune disorders, such as Hashimoto’s.

This test checks for elevated antibodies created against thyroid peroxidase (TPO), an enzyme that helps produce hormones. Therefore, if antibodies are detected with this test, it can indicate thyroid-related autoimmune disorders, such as Hashimoto’s. Comparing this test with abnormal levels of thyroid-stimulating hormone may indicate Graves’ disease.

About 1 in 5 women and 1 in 10 men have hypothyroidism, and a TSH test can help reveal thyroid issues. Looking at abnormal TSH results alongside thyroid peroxidase (TPO) may be a sign of Graves’ disease. TSH is produced by the pituitary gland and controls the release of thyroid hormones: triiodothyronine (T3) and thyroxine (T4).

This test is typically cross-referenced with TSH and T3 to gain insight into overall thyroid function. Thyroxine, or T4, is produced in the thyroid then released into the bloodstream where it travels to the liver and kidneys. It is converted into the hormone triiodothyronine (T3). The synergy of T4 and T3 is important for heart and digestive function, metabolism, brain development, bone health, and muscle control.

T3 levels can reveal an overactive (hyperthyroidism) or underactive (hypothyroidism or Hashimoto’s) thyroid. T3 is the most powerful thyroid hormone in the body. It helps regulate body temperature, control heart rate, lower cholesterol, improve memory, promote regrowth after hair loss, soothe muscle aches, regulate bowel movements, and support fertility.

Iodine levels give insight into thyroid health. The thyroid gland absorbs iodine to produce T4 and T3 hormones, to prevent goiters and help the body make protein and use oxygen. *This add-on test is available for an additional cost and is not included in the £399 membership.

Selenium looks into the health of the liver, thyroid hormones, and kidneys. Selenium is a trace mineral found in soil that helps the body produce the antioxidant glutathione, which alleviates oxidative stress. It also stimulates thyroid hormones that aid in heart and digestive function, metabolism, brain and bone health, and muscle control. *This add-on test is available for an additional cost and is not included in the £399 membership.

In partnership with Grail, the Galleri® multi-cancer early detection test detects cancer signals across 50+ types of cancer as early as stage one. Test annually and stay vigilant for early warning signs. *This add-on test is available for an additional cost and is not included in the £399 membership.Types of cancer tested: Adrenal Cortical Carcinoma, Ampulla of Vater, Anus, Appendix, Carcinoma, Bile Ducts, Bladder, Urinary, Bone, Breast, Cervix, Colon and Rectum, Esophagus and Esophagogastric Junction, Gallbladder, Gastrointestinal Stromal Tumor, Gestational Trophoblastic Neoplasms, Kidney, Larynx, Leukemia, Liver, Lung, Lymphoma (Hodgkin and Non-Hodgkin), Melanoma of the Skin, Merkel Cell Carcinoma, Mesothelioma, Nasal Cavity and Paranasal Sinuses, Nasopharynx, Neuroendocrine Tumors, Oral Cavity, Oropharynx, Ovary, Fallopian Tube and Primary Peritoneum, Pancreas, Penis, Plasma Cell Myeloma and Plasma Cell Disorders, Prostate, Small Intestine, Soft Tissue Sarcoma, Stomach, Testis, Ureter, Renal Pelvis, Uterus, Vagina, and Vulva.

Measuring one's PSA screens for tumors and/or monitors preexisting prostate cancer. On its own, it can not be used to diagnose cancer. Rather, this test and one's total PSA reveals the health of your prostate and acts as a signal if something is wrong.

This percentage helps determine the risk of prostate cancer and is often referred to if a doctor is deciding whether or not to conduct a biopsy. The percentage is calculated by dividing free PSA by total PSA and multiplying it by 100%.

Measuring one's PSA screens for tumors and/or monitors preexisting prostate cancer. On its own, it can not be used to diagnose cancer. Rather, this test and one's free PSA reveals the health of your prostate and acts as a signal if something is wrong.

The Antinuclear Antibodies (ANA) Pattern test analyzes the specific patterns of antibody staining on cells, providing detailed information that can aid in diagnosing and differentiating various autoimmune diseases. Different patterns, such as homogeneous, speckled, nucleolar, and centromere, are associated with specific autoimmune conditions, helping healthcare providers pinpoint the exact nature of the autoimmune response. This result is only processed if ANA screen is positive.

The Antinuclear Antibodies (ANA) Screen is a blood test that detects the presence of antibodies that mistakenly target and attack the nucleus of the body's cells. A positive ANA test suggests an autoimmune response, but further tests are usually required to determine the specific condition and guide appropriate treatment.

An ANA test assists in detecting autoimmune disorders. ANAs are autoantibodies produced by the immune system. While healthy antibodies protect the body from pathogens like viruses and bacteria, autoantibodies cause disease by mistakenly attacking healthy cells and tissues. This result is only processed if ANA screen is positive.

Approximately 20% of people with celiac disease, an autoimmune disorder triggered by gluten, are asymptomatic. However, even without symptoms, untreated celiac disease may chip away at the immune system, which can lead to Type 1 diabetes, multiple sclerosis, anemia, osteoporosis (due to issues with nutrient absorption), and skin conditions. *This add-on test is available for an additional cost and is not included in the £399 membership.

Rheumatoid factors (RFs) are antibodies produced by the immune system. The presence of RFs can indicate autoimmune disorders such as rheumatoid arthritis, rheumatoid vasculitis, or Sjögren’s syndrome. Asymptomatic individuals with elevated RF levels may have pre-autoimmunity.

Basophils account for only around 1% of white blood cells but play a role in allergy defense and stimulate antibodies against pathogens and parasitic organisms (such as ticks and worms) that cause injury or infection.

Eosinophils are recruited to inflamed areas of the body to trap substances, kill infected cells, viruses, parasites, and bacteria, and help tame an allergic response. Testing can reveal issues in the digestive tract, specifically the esophagus, and includes both percentage and absolute levels.

Lyme disease can go undetected (and therefore untreated) for years after initial infection. Testing for Lyme is incredibly important because it can eventually lead to brain and nerve damage. Lyme disease is the most common tick-borne illness in North America and is difficult to diagnose because its symptoms — more than 100 of them — can mimic other conditions like the flu, multiple sclerosis, lupus, and arthritis. *This add-on test is available for an additional cost and is not included in the £399 membership.

The Lyme IgM test is a blood test used to detect IgM antibodies in response to the bacterium Borrelia burgdorferi, which causes Lyme disease. The presence of IgM antibodies indicates early-stage Lyme infection. *This add-on test is available for an additional cost and is not included in the £399 membership. This result is only processed if Lyme Antibody is positive or equivocal.

The test is usually done with a Lyme IgG test for a more accurate diagnosis. *This add-on test is available for an additional cost and is not included in the £399 membership. This result is only processed if Lyme Antibody is positive or equivocal.

Lymphocyte levels can reveal a number of conditions, including autoimmunity, bone marrow disorders, kidney disease, gastrointestinal disorders, and more. The role of lymphocytes in the body’s immune defense is so crucial that abnormal levels can weaken the body, leading to severe illness or impairing its ability to fight off infections. The test includes both percentage and absolute levels.

Like other white blood cells (WBCs), monocytes help the immune system destroy invaders and also facilitate healing and repair. Abnormal levels can indicate bacterial infections, virus or fungus, stress, chronic infections, or autoimmune disorders. The test includes both percentage and absolute levels.

Testing the quantity of neutrophils helps detect damage caused by inflammatory disorders (such as rheumatoid arthritis and gout), infections (both acute and chronic), certain cancers (such as myelocytic leukemia), and physical stressors (including eclampsia in pregnant women, injury, and burns). Neutrophils are key patrols and first responders in the immune system, attacking antigens they encounter. The test includes both percentage and absolute levels.

A healthy WBC baseline over time correlates with the body's ability to fight off diseases and other hazards. Prolonged abnormalities can negatively affect biological age by impairing healing and increasing the risk of illness.

hs-CRP is revelatory in one's overall health as it relates to the risk of inflammation-related diseases. Chronic inflammation is linked to every major disease: heart disease (even before symptoms occur), type 2 diabetes, cancer, high blood pressure, Alzheimer’s, depression, all autoimmune diseases, and severe allergic reactions like asthma.

AMH is a key fertility marker that assesses ovarian reserve (egg count) at the time of the test. This test sheds light on the body’s potential to produce eggs for fertilization, particularly if one is nearing menopause or experiencing a hormonal condition such as polycystic ovary syndrome (PCOS) or primary ovarian insufficiency (POI).

A positive beta human chorionic gonadotropin (hCG) level is used for early detection of pregnancy. Pregnancy tests detect the hCG hormone in both blood and urine. *This add-on test is available for an additional cost and is not included in the £399 membership.

When SHBG levels change, it can impact the amount of available hormones in the body, either too much or too little. This can affect the menstrual cycle as well as fertility. SHBG patrols the amount of sex hormones the body tissues can use.

This helps evaluate functions associated with testosterone levels, such as fertility, sexual function, muscle mass, energy, mood, insulin resistance/sensitivity, and pituitary function. It can also detect prediabetes, PCOS, or menopause. Evolve tests both "free" and “total” testosterone in the blood.

In all adults, healthy levels of testosterone are important for general health, body composition, sexual function, and reduced risk of disease. Evolve tests both "free" and “total” testosterone in the blood.

FSH evaluates ovarian health and pituitary function, and can help determine a diagnosis of polycystic ovary syndrome (PCOS), perimenopause, or menopause. As a type of protein hormone, FSH is responsible for stimulating the ovarian follicles that produce and release eggs during ovulation. If one is on hormonal birth control, this test will not be run.

LH levels give insight into sexual development and fertility. LH releases estrogen during the menstrual cycle, which triggers the release of an egg from the ovary**, otherwise known as ovulation.** It can also help determine states of perimenopause and menopause. If one is on hormonal birth control, this test will not be run.

Prolactin levels can guide the diagnosis of irregular or absent menstrual periods, infertility, menopausal symptoms, osteoporosis, liver or kidney disease, hypothyroidism, and/or estrogen and testosterone deficiency, in addition to unwanted lactation. It is also used to screen for pituitary tumors. Prolactin is a peptide hormone produced by the pituitary gland and stimulates breast development and milk production in pregnant women.

For biological females, testing the hormone estradiol (one type of estrogen) is key in detecting menopause, polycystic ovarian syndrome (PCOS), androgen- or estrogen-producing tumors, uterine and breast cancer, and mitigating the risk of osteoporosis and cardiovascular disease. If one is on hormonal birth control, this test will not be run.

DHEA Sulfate, the most abundant hormone in the human body, is associated with longevity, positive reproductive outcomes, and immune system regulation. This test can gauge reproductive function and the health of your adrenal gland.

In all adults, healthy levels of testosterone are important for general health, body composition, sexual function, and reduced risk of disease. Evolve tests both "free" and “total” testosterone in your blood. One will naturally have a higher level of "total" than "free.”

DHEA-S can gauge the health of the reproductive system and adrenal glands. It is one of three adrenal androgens: steroid hormones that control the development and maintenance of masculine characteristics.

For biological males, testing the hormone estradiol (one type of estrogen) is key in understanding testosterone levels and sexual function. Estradiol is essential in sexual development and managing the reproductive system.

FSH levels share insight into one's fertility, along with testicle and pituitary health. Strong levels are necessary for healthy male hormonal function, and are partially responsible for sperm production and sexual development.

LH helps the testicles make testosterone, which is important for producing sperm and many other male functions. LH levels gives insight into one's sexual development and fertility.

Measuring one's PSA screens for tumors and/or monitors preexisting prostate cancer. On its own, it can not be used to diagnose cancer. Rather, this test and one's total PSA reveals the health of your prostate and acts as a signal if something is wrong.

This percentage helps determine the risk of prostate cancer and is often referred to if a doctor is deciding whether or not to conduct a biopsy. The percentage is calculated by dividing free PSA by total PSA and multiplying it by 100%.

Measuring one's PSA screens for tumors and/or monitors preexisting prostate cancer. On its own, it can not be used to diagnose cancer. Rather, this test and one's free PSA reveals the health of your prostate and acts as a signal if something is wrong.

When SHBG levels change, it can impact the amount of available hormones in the body, either too much or too little. This can impact sexual function and fertility. SHBG patrols the amount of sex hormones the body tissues can use.

Prolactin levels can guide diagnosis of low libido or erectile dysfunction, or screen for pituitary tumor. Prolactin is a peptide hormone produced by the pituitary gland.

This helps evaluate functions associated with testosterone levels, such as fertility, sexual function, muscle mass, energy, mood, insulin resistance/sensitivity, and pituitary function. It can also screen for prediabetes. Evolve tests both "free" and “total” testosterone in the blood.

Insulin levels can uncover reasons behind abnormal blood sugar, insulin resistance, and more. It can also reveal hidden blood sugar issues even years before they escalate to something like diabetes. Establishing one's insulin baseline can be incredibly insightful to how one's lifestyle affects health.

Leptin tells the brain when to stop eating. It is a hormone created by fat cells that regulates energy expenditure, and this test is an important diagnostic tool for leptin deficiency, which causes obesity and chronic inflammation. High levels are often associated with vascular risk factors, including insulin resistance, diabetes mellitus, hypertriglyceridemia, and hypertension.

Uric acid in the blood screens for metabolic disorders, like gout, anemia, and immunodeficiencies. This often overlooked test has renewed attention after recent studies show elevated levels can increase the risk of death from cardiovascular issues by 39% and stroke by 35%.

HbA1c is the average amount of glucose attached to blood cells over the last 90 days. It diagnoses, monitors, and screens for prediabetes and diabetes. This test is a revelatory look into one's health, specifically the body’s ability to control blood sugar. Unhealthy levels are triggered by inflammation, vitamin deficiencies, kidney damage, thyroid disorders, and more. One's diet and habits can have a substantial impact on this test.

Too much glucose (hyperglycemia) is a major driver of many diseases and illnesses, including cancer, diabetes, high blood pressure, heart attacks, kidney disease, and Alzheimer’s disease. Glucose is a type of sugar (from food) that the body uses for energy. When glucose is not absorbed and used, it can form glycogen and be stored as fat in the liver. Over time, this can lead to a decline in overall health.

Adiponectin abnormalities are an indicator of metabolic disorders, such as obesity, type 2 diabetes, and heart disease. Adiponectin is a growth hormone, like prolactin and insulin, that influences body weight and metabolism by combating inflammation, regulating glucose, metabolizing lipids, and controlling insulin response. *This add-on test is available for an additional cost and is not included in the £399 membership.

This ratio helps assess inflammation and the management of heart disease and other chronic/inflammatory processes.

Calcium levels help understand symptoms related to the kidneys, bones, thyroid, parathyroid, or nerves. Calcium is a mineral the body uses to build and maintain strong bones, teeth, muscle control, and blood circulation.

Healthy copper levels are important because copper is a vital mineral that helps the body metabolize iron and make and regenerate melanin, bones, and connective tissues, among other essential processes. However, untreated copper toxicity can become hazardous to the heart, kidneys, liver, and brain. *This add-on test is available for an additional cost and is not included in the £399 membership.

Ferritin levels can help diagnose iron deficiency, liver disease, inflammation, or insulin resistance. Ferritin is a protein that stores iron in cells and then releases the iron when the body makes more red blood cells.

A homocysteine test checks the body’s vitamin B levels and methylation function, a key biochemical process essential for almost all of the body’s systems. Abnormal homocysteine can build up and increase the risk of blood clots, dementia, osteoporosis, heart disease, heart attack, and stroke. Homocysteine is an amino acid that helps organs grow and regenerate.

Iodine levels give insight into thyroid health. The thyroid gland absorbs iodine to produce T4 and T3 hormones, to prevent goiters and help the body make protein and use oxygen. *This add-on test is available for an additional cost and is not included in the £399 membership.

Healthy iron levels create vitality throughout the entire body. Iron helps various vital functions, like providing energy and focus, building a strong gastrointestinal tract and immune system, and regulating body temperature. Iron deficiency can lead to numerous biological problems, including anemia.

TIBC assesses the body’s ability to transport iron in the blood, and can diagnose and/or monitor iron-deficiency or iron overload. Lower than normal levels of TIBC could indicate too much iron and a variety of conditions, including anemias, inflammation, or liver disease.

The Iron % Saturation test measures the percentage of transferrin, a protein that transports iron in the blood, that is saturated with iron. This test is crucial for assessing iron status in the body and can help diagnose conditions such as iron deficiency anemia or iron overload disorders like hemochromatosis.

Magnesium is a mineral imperative for cells to make energy, for chemical pumps to work and stabilize membranes, and to help muscles relax. Low magnesium can impact calcium, potassium, phosphorus, and/or parathyroid hormone. This test helps evaluate absorption and helps determine whether or not there’s a problem with kidney function or the gastrointestinal tract.

MMA measures vitamin B12 and can detect a deficiency even when mild or just beginning. MMA is a key component for metabolism and energy, and because blood and/or urine levels of MMA rise when B12 levels drop, it is a more sensitive biomarker than testing just B12 levels.

Measures the amount of DHA, DPA, and EPA, omega-3 essentials for brain function and development.

‍To ensure timely results, this test may be completed during Mid-Year visits.

Omega-3 fatty acids, including EPA and DHA, are essential for reducing inflammation, supporting heart health, and promoting brain function. This test is important because adequate omega-3 levels are associated with a lower risk of heart disease, better inflammatory response, and improved mental health.

‍To ensure timely results, this test may be completed during Mid-Year visits.

Measures this pro-inflammatory omega-6 fatty acid, which can increase the risk of inflammatory diseases and mood disorders if chronically elevated.

‍To ensure timely results, this test may be completed during Mid-Year visits.

Linoleic acid is a key omega-6 fatty acid essential for cell membrane structure and function and is a precursor to arachidonic acid, which plays a significant role in the body's inflammatory processes. Elevated levels of linoleic acid can indicate excessive dietary intake, which may contribute to chronic inflammation and increase the risk of cardiovascular disease.

‍To ensure timely results, this test may be completed during Mid-Year visits.

While omega-6 is typically higher than omega-3, ensuring that this ratio remains low is important.

‍To ensure timely results, this test may be completed during Mid-Year visits.

Imbalanced omega-3 and omega-6 levels are a risk factor for cardiovascular disease, age-related macular degeneration, rheumatoid arthritis, cancer, and more. Omegas are essential fatty acids (EFAs), which are the building blocks for every cell in the body. Well-balanced omegas can contribute to optimal brain performance, mental health, nerve function, a healthy heart, circulation, immune system, gastrointestinal tract, skin, hair, and nails.

‍To ensure timely results, this test may be completed during Mid-Year visits.

Selenium looks into the health of the liver, thyroid hormones, and kidneys. Selenium is a trace mineral found in soil that helps the body produce the antioxidant glutathione, which alleviates oxidative stress. It also stimulates thyroid hormones that aid in heart and digestive function, metabolism, brain and bone health, and muscle control. *This add-on test is available for an additional cost and is not included in the £399 membership.

Vitamin D deficiency is widely underdiagnosed and undertreated. Over time, low levels can lead to hypothyroidism, osteoporosis, cancer, heart disease, fatigue, depression, seasonal affective disorder (SAD), gut issues, and fibromyalgia. The role of vitamin D is vast and benefits the immune system, thyroid, bones and teeth, muscles, and brain.

Zinc is mostly known for its immune support, but it's actually a powerful mineral across all systems of the body: from strengthening bones and muscles, preventing blood clotting and metal accumulation, promoting proper insulin and thyroid function, and so much more. If deficient, it can impact mood, sexual function, and immunity.

Biological age reflects how one's body is aging at the cellular and molecular levels, which can determine the risk of age-related conditions like cardiovascular diseases and cognitive decline. Unlike calendar age (number of years lived), biological age is reversible and something one can optimize. It calculates mortality risk and phenotypic age based on various lab test results. While biological age on its own might seem like a vanity metric, when combined with 100+ lab tests, it offers a comprehensive benchmark for tracking and enhancing health and longevity.

Cortisol, for one, is often referred to as “the stress hormone.” However, it goes beyond stress to help the body with numerous functions. Testing can detect imbalances in adrenal function.

DHEA Sulfate, the most abundant hormone in the human body, is associated with longevity, positive reproductive outcomes, and immune system regulation. This test can gauge reproductive function and the health of your adrenal gland.

IGF-1 is known as the "growth hormone" because it stimulates growth in cells throughout the body. This leads to growth and development (from the womb and through adolescence), strengthening of tissues (e.g. improving bone density, building muscle), and healing (e.g. skin, bones, gut lining), depending on what the body needs. *This add-on test is available for an additional cost and is not included in the £399 membership.

ALT is an enzyme that checks on liver health. If one's liver cells are damaged due to excess alcohol, drugs, disease, or injury, ALT will appear in the bloodstream and, therefore, in a blood test.

Abnormal albumin can indicate malnutrition, liver or kidney disease, or a digestive inflammatory condition (Crohn’s or Celiac) resulting in malabsorption. Albumin is a protein made by the liver that helps fluid remain in the bloodstream rather than leaking into other tissues. It also helps hormones, vitamins, and enzymes transfer throughout the body to their final destinations.

ALP can help detect and/or monitor conditions related to the liver, malnutrition, autoimmune disorders, or bone disease. ALP is an enzyme that breaks down proteins. It is found throughout the entire body, but is mostly prevalent in the liver, bones, intestines, and kidneys.

AST is an enzyme mostly found in the liver and helps metabolize amino acids. Testing for AST in the blood can help detect liver damage from injury or a number of diseases and conditions, like hepatitis, cirrhosis, mononucleosis, or other liver diseases, heart problems, or pancreatitis.

Monitor liver health with GGT. This test helps detect liver disease, identify bile duct blockages, and check for conditions related to alcohol and toxins. The GGT biomarker is a reliable detector (but not a diagnostic test) for toxin exposure or fatty liver from alcohol, even when other liver tests are normal.

In tandem with a full liver panel, this test can help determine the cause of jaundice and/or help diagnose conditions such as liver disease, hemolytic anemia, or blockage of the bile ducts. The liver makes bile to help digest food, and bile contains bilirubin. A healthy liver can get rid of bilirubin, but when the liver isn't working properly, it cannot break down bilirubin and dispose of it.

Protein levels explore the health of the kidneys, liver, and absorption processes. The human body is made up of thousands of proteins, all of which have various roles in making and maintaining every cell in the body, including enzymes and hormones. Proteins also fuel those cells and the immune system with energy.

Globulin is a protein essential for liver function, blood clotting, and immune system operations. Abnormal globulin levels can indicate various conditions, such as liver disease, autoimmune disorders, or chronic infections.

Keep an eye on kidney health with microalbumin. This test checks for small fragments of albumin in one's urine, which may be an early indication of kidney damage due to hypertension or type 2 diabetes. Microalbumin will show issues even before the normal kidney tests (creatinine and BUN) are elevated.

Urea nitrogen is a waste product that the kidneys flush out, but the presence or buildup of urea nitrogen waste in the blood means the kidneys aren't regulating waste properly. Compared to one's creatinine levels, this test can screen for kidney disease.

This ratio helps evaluate kidney function and can indicate conditions such as dehydration, kidney disease, or issues affecting kidney perfusion. A high ratio may suggest dehydration or upper gastrointestinal bleeding, while a low ratio can point to acute tubular necrosis or liver disease. This result is only calculated if BUN is out of range.

Calcium levels help understand symptoms related to the kidneys, bones, thyroid, parathyroid, or nerves.

Chloride is a mineral in the body that creates channels in cell membranes to carry out vital tasks. This test can help detect dehydration, kidney disease, liver disease, heart failure, high blood pressure, or other disorders.

Creatinine levels vary from person to person, but abnormalities typically signal kidney disease or damage. One's creatinine levels are directly related to lifestyle, diet, medication, and how those can impact the kidneys’ ability to function. Creatinine (not to be confused with creatine) is a chemical compound left over from everyday wear and tear of the muscles.

(eGFR)eGFR is a kidney biomarker, and this test is used to help diagnose kidney disease at an early stage when it is most treatable. It can also track those with pre-existing kidney-related conditions.

Potassium is an electrolyte that aids in muscle contraction, digestion, messaging from the brain to the body, and regulating fluids and blood pressure. Potassium levels can help detect kidney, liver, heart, and blood disorders.

A sodium test looks at electrolytes and pH. When sodium levels are abnormal, it can signal issues with the brain, lungs, liver, heart, kidneys, thyroid, and adrenal glands.

Amylase checks in on the pancreas, and irregular levels can detect salivary disease, celiac disease, IBD, and the growth of a tumor in an amylase-producing tissue. Amylase is an enzyme produced in the salivary glands and pancreas. It’s a digestive protein that breaks down carbohydrates and starches into simple sugars, giving the body energy.

A lipase test is able to show swelling or inflammation in the pancreas, a condition known as pancreatitis. It can also reveal other health conditions such as kidney disease, pancreatic cancer, and problems with the gallbladder or esophagus. Lipase is an enzyme produced by the pancreas that helps the body digest fats.

The form of aluminum that causes harm is present in many everyday household and personal care products. An aluminum test detects whether or not there has been an overexposure to aluminum. Too much impairs iron absorption and can lead to faulty hematopoiesis--the process through which the body makes red blood cells. *This add-on test is available for an additional cost and is not included in the £399 membership.

Arsenic is a neurotoxin that can lead to hypertension, infertility, neurological disorders, and peripheral neuropathy (pain in the hands and feet). Arsenic comes in two forms: organic and inorganic, used in manufacturing and mining. Arsenic can be found in seafood, wine, groundwater, and more. *This add-on test is available for an additional cost and is not included in the £399 membership.

Lead is a common element all around us and is naturally absorbed, but it can be dangerous if exposed to hazardous sources. Untreated toxicity can lead to fertility complications, kidney failure, convulsions, cardiovascular issues, hormonal disruption, gastrointestinal issues, and neurological changes.

Mercury is a neurotoxin that can result in kidney damage, brain damage, and fertility issues. It is found everywhere: fish, coal, plastics, pesticides, mercury amalgam dental fillings, and more. In 2022, the US government reaffirmed regulations to curtail mercury pollution from power plants. Testing mercury levels over time and establishing a baseline provides an understanding of why and how one may be exposed to mercury.

Know your blood type! This information is important not only in case of an emergency where one might need a blood transfusion but also if you want to donate blood to help others. Blood type is also a predictor for some conditions that occur during pregnancy and/or if one is susceptible to blood clotting or kidney stones.

As part of the complete blood count, an HCT test measures the percentage of red blood cells in the blood. This test helps screen for, diagnose, and monitor conditions that affect the blood or bone marrow.

Hemoglobin reflects the number of red blood cells active in the blood. Low levels may uncover anemia, vitamin deficiencies, loss of blood (both internal and external), and chronic diseases. The test can also help detect diseases affecting the lungs, liver, kidneys, or cardiovascular system, significant long-term infection, cognitive impairment, and certain types of cancer, and diagnose chronic blood disorders.

MCHC measures the amount of hemoglobin per unit volume. So, this test assesses the hemoglobin content within the volume of the cell, which can uncover iron-deficiency anemia, hypothyroidism, spherocytosis, or RBC agglutination.

MCH is usually done as part of the complete blood count and can help detect various types of anemia (deficiency in iron, B12, or folate), blood loss, cancer, kidney or liver disease, or autoimmunity. MCH measures the average amount of hemoglobin in the red blood cells.

MCV's insight into the blood is a unique indicator of overall health. If MCV is either high or low overtime (most likely indicating a chronic vitamin deficiency or blood condition), it can degrade the body's general wellness and thus one's phenotypic age. MCV measures average size of red blood cells: whether they are too big, too small, or just right.

Mean Platelet Volume (MPV) measures the mass of platelets, which is important in determining the cause of thrombocytopenia (a low platelet count) or thrombocytosis (a high platelet count). So, why does MPV matter? When platelets are healthy, there is a dynamic relationship between their size and count.

Abnormal platelet count is a risk marker for heart attack, stroke, and other heart diseases, but this test can also help diagnose autoimmune disease, bone marrow damage (which can be caused by certain cancers, such as leukemia and/or cancer treatments), spleen disorder, and parasites. Platelets, which are made in the bone marrow, are small, colorless blood cells that form clots with the goal of stopping or preventing bleeding.

RBC count can reveal various anemias, vitamin deficiencies, colon, bladder, or kidney issues, chronic diseases that cause bone marrow suppression, autoimmune disorders, blood disorders, polycythemia vera, congenital heart disease, and more.

RDW is the size and volume of the red blood cells. RDW and MCV explore one's overall health, and together, they can detect liver disease and various types of vitamin-deficiency anemias even before symptoms occur. When either or both are abnormal over time, it can lead to a higher risk of disease and increase one's phenotypic age.

Calcium levels help understand symptoms related to the kidneys, bones, thyroid, parathyroid, or nerves.

A chloride test is useful in diagnosing the underlying causes of abnormal fluid levels or pH balances, such as dehydration, kidney disease, liver disease, heart failure, high blood pressure, or other disorders. Chloride is a major mineral in the body that manufactures channels in cell membranes, which carry out different vital tasks.

Magnesium is a mineral imperative for cells to make energy, for chemical pumps to work and stabilize membranes, to help muscles relax, and so much more.

Potassium levels can detect kidney disease, liver disease, heart failure, high blood pressure, or other disorders. As an electrolyte, potassium helps muscles contract, aids digestion, allows nerves to transport messages from the brain to the body, and balances fluids and regulates blood pressure.

A sodium test looks at electrolytes and pH. When sodium levels are abnormal, it can signal issues with the brain, lungs, liver, heart, kidneys, thyroid, and adrenal glands.

Carbon dioxide (bicarbonate) levels monitor pH and/or electrolyte balance. When irregular, it can be a sign of dehydration, kidney disease, liver disease, heart failure, high blood pressure, or other disorders. Bicarbonate is an alkali of the electrolyte family. As an alkali, it plays a role in balancing the acid-base in pH balance.

Albumin is a foundational protein found in the blood. In early kidney damage—most commonly from hypertension or type 2 diabetes—smaller fragments of albumin called microalbumin appear in the urine.

Checks the clarity of urine from clear to turbid.

Healthy urine is sterile, so when bacteria is present, it's a sign of infection.

Look into the general health of the liver. When healthy, the liver makes bile, which contains bilirubin. This bile helps digest food, and a thriving liver gets rid of excess bilirubin, but when the liver isn't working properly, bilirubin builds up.

The clarity of urine, from clear to turbid, explores the health of one's kidneys and urinary tract.

An unusual urine color can be a sign of disease, such as a kidney disorder or urinary tract infection (UTI). The scale from light to dark gives a picture of how much water is being flushed through a system.

If one is healthy, glucose levels in the urine are generally too low to be detected. Glucose in the urine, or glucosuria, is a symptom of both type 1 diabetes and type 2 diabetes (when one's blood sugars are high), pregnancy, or liver abnormalities or hormonal disorders.

It's ok if hyaline casts show up in urine. However, large amounts of them may indicate kidney damage due to decreased blood flow to the kidneys.

Ketone testing can help diagnose ketoacidosis or diabetic ketoacidosis (DKA), a complication of diabetes, or issues unrelated to diabetes like gastrointestinal diseases (IBS, colitis, Crohn’s, celiac, GERD). Ketones are produced in the liver as part of a body’s metabolism process. If one is low on glucose, the body burns fat for energy instead and produces ketones, which show up in urine. This is the process behind ketogenic (keto) diets.

Leukocytes are white blood cells (WBCs), which are vital to health! However, if they're detected in urine, it may be a sign of inflammation in the urinary tract or kidneys.

Increased nitrites in urine can indicate an infection in the urinary tract, anywhere from the kidneys, renal pelvis, ureters, bladder, and urethra. Healthy urine has chemicals called nitrates. When bacteria enter the urinary tract, nitrates can transform into nitrites.

This test detects blood in urine, which could potentially indicate a urinary tract infection (UTI), enlarged prostate, kidney damage (from injury), kidney disease, or other kidney or bladder-related conditions.

The goal of testing pH is to identify whether or not one has an acid-base imbalance, to determine how severe the imbalance is, and to help diagnose underlying diseases or conditions (such as diabetic ketoacidosis, a life-threatening complication of diabetes). Testing also helps monitor critical illnesses that affect acid-base balance, such as chronic lung disease and kidney disease.

The goal of this test is to evaluate kidney function. Normally, protein stays in the blood and doesn't pass into urine. The kidneys prevent this from happening. If proteinuria (protein in urine) is detected, the kidneys aren't functioning properly.

Red blood cells carry oxygen from the lungs to the rest of the body and return carbon dioxide for exhalation. This test helps detect conditions such as anemia, dehydration, and polycythemia. Abnormal RBC levels can indicate various health issues, including nutritional deficiencies, bone marrow disorders, and chronic illnesses.

Specific Gravity is the concentration of the urine, which is a quick way to tell if the kidneys are trying to compensate for an abnormality. This test helps convey overall kidney health and can screen for renal tubular necrosis, diabetes insipidus, kidney failure, low levels of sodium in the blood, or a severe kidney infection.

It's normal to have a small amount of epithelial cells in urine. A large amount, however, may indicate an infection, kidney disease, or another serious medical condition.

White blood cells play a vital role in defending the body against infections, inflammation, and diseases. This test is essential for diagnosing and monitoring conditions such as infections, leukemias, autoimmune disorders, and bone marrow disorders. Abnormal WBC counts can indicate an active infection, an immune response, or an underlying medical condition.

The presence of yeast in urine suggests a potential fungal infection, commonly due to Candida species, and may indicate a urinary tract infection (UTI) or a vaginal yeast infection.

ApoE is a predictive genetic biomarker for Alzheimer’s disease, currently one of the leading causes of death in the United States. The result of this test illuminates personal risk, even decades before the onset of the disease. Holding this wisdom, along with the health of a brain's support systems (many of which are part of your Evolve biomarkers), can potentially help avert onset completely. *This add-on test is available for an additional cost and is not included in the £399 membership.

The IgE allergy test looks at whether you are susceptible to the classic food allergies: peanuts, tree nuts, dairy, eggs, gluten, soy, fish, and shellfish. *This add-on test is available for an additional cost and is not included in the £399 membership.

Tests susceptibility to allergens commonly found in mold, dander, mouse dust, insects and venom, storage mites, and select grasses, trees, and weeds based on one's region. *This add-on test is available for an additional cost and is not included in the £399 membership.

Chlamydia is a sexually transmitted disease easily contracted through vaginal, oral, and anal sex. It is the most common STD in the United States. Many people are asymptomatic, and if left untreated, it can have serious health consequences, including infertility. *This add-on test is available for an additional cost and is not included in the £399 membership.

Some individuals with gonorrhea are asymptomatic. If left untreated, gonorrhea may cause a number of serious health conditions and diseases in both men and women. *This add-on test is available for an additional cost and is not included in the £399 membership.

Both herpes type 1 (HSV-1) and type 2 (HSV-2) may occur in the mouth and the genitals. More than 50% of individuals in the United States have oral herpes, usually acquired during childhood. Once contracted, the initial infection resolves but the virus itself remains dormant in the body. During periods of stress or illness, the virus can reactivate. *This add-on test is available for an additional cost and is not included in the £399 membership.

This test checks for both types of HIV: HIV-1, the most common type of HIV that accounts for 95% of all infections, and HIV-2, which is relatively uncommon and less infectious. *This add-on test is available for an additional cost and is not included in the £399 membership.

Syphilis is passed from partner to partner when infected lesions come in contact with the vagina or urethra, or when an abrasion is present during vaginal, oral, and anal sex, even in the absence of penetration. Left undetected and untreated, complications may be irreversible. *This add-on test is available for an additional cost and is not included in the £399 membership.

A parasite called Trichomonas (trich) vaginalis causes this STD. It is a very common but curable STD. Many people are asymptomatic and are unaware they’re infected, which makes it easy to spread to others unknowingly. *This add-on test is available for an additional cost and is not included in the £399 membership.

Biological age reflects how the body is aging at the cellular and molecular levels, which can determine the risk of age-related conditions like cardiovascular diseases and cognitive decline. Unlike calendar age (number of years lived), biological age is reversible and something one can optimize. It calculates mortality risk and phenotypic age based on various lab test results. While biological age on its own might seem like a vanity metric, when combined with 100+ lab tests, it offers a comprehensive benchmark for tracking and enhancing health and longevity.